Drug interactions
Benperidol + Clorazepate
Severity: Moderate
Benperidol and Clorazepate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benperidol is a potent butyrophenone antipsychotic, and with clorazepate sedation, drowsiness and psychomotor impairment can increase. Respiratory depression is possible, especially at high doses or in vulnerable patients.
What this interaction means in plain words
Benperidol and Clorazepate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A potentiation and dopamine blockade with sedative effects.
What to do
Monitor sedation and respiratory status, and use the lowest effective doses. Avoid alcohol and other CNS depressants.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Frequently asked questions
Can I take Benperidol with Clorazepate?
MediHelp rates the interaction as moderate. Benperidol and Clorazepate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benperidol is a potent butyrophenone antipsychotic, and with clorazepate sedation, drowsiness and psychomotor impairment can increase. Respiratory depression is possible, especially at high doses or in vulnerable patients.
How serious is the interaction between Benperidol and Clorazepate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status, and use the lowest effective doses. Avoid alcohol and other CNS depressants.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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