Drug interactions
Benperidol + Desflurane
Severity: Moderate
Benperidol and Desflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benperidol is a potent butyrophenone antipsychotic that causes sedation and can prolong the QT interval. With desflurane it may add to CNS depression and hypotension and increase arrhythmia risk.
What this interaction means in plain words
Benperidol and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and alpha-blockade, with possible additive QT prolongation.
What to do
Check ECG and electrolytes preoperatively and monitor ECG and blood pressure during anesthesia. Titrate desflurane to effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desflurane
Frequently asked questions
Can I take Benperidol with Desflurane?
MediHelp rates the interaction as moderate. Benperidol and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benperidol is a potent butyrophenone antipsychotic that causes sedation and can prolong the QT interval. With desflurane it may add to CNS depression and hypotension and increase arrhythmia risk.
How serious is the interaction between Benperidol and Desflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes preoperatively and monitor ECG and blood pressure during anesthesia. Titrate desflurane to effect.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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