Drug interactions
Benperidol + Glycopyrronium
Severity: Moderate
Benperidol and Glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benperidol has some anticholinergic activity, and glycopyrronium adds to peripheral anticholinergic effects such as dry mouth, constipation, urinary retention and tachycardia. Anticholinergics may also be given to treat extrapyramidal symptoms from antipsychotics, but excess dosing risks heat intolerance and confusion.
What this interaction means in plain words
Benperidol and Glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects; anticholinergics may also slow gastric emptying and alter oral antipsychotic absorption.
What to do
Monitor for anticholinergic adverse effects, including constipation, urinary retention and overheating, and reduce the dose if troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glycopyrronium
- Clozapine + Glycopyrronium Major
- Abobotulinumtoxina + Glycopyrronium Moderate
- Aclidinium + Glycopyrronium Moderate
- Amantadine + Glycopyrronium Moderate
- Amitriptyline + Glycopyrronium Moderate
- Amoxapine + Glycopyrronium Moderate
Frequently asked questions
Can I take Benperidol with Glycopyrronium?
MediHelp rates the interaction as moderate. Benperidol and Glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benperidol has some anticholinergic activity, and glycopyrronium adds to peripheral anticholinergic effects such as dry mouth, constipation, urinary retention and tachycardia. Anticholinergics may also be given to treat extrapyramidal symptoms from antipsychotics, but excess dosing risks heat intolerance and confusion.
How serious is the interaction between Benperidol and Glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects, including constipation, urinary retention and overheating, and reduce the dose if troublesome.
What other medicines interact with Glycopyrronium?
MediHelp also lists interactions of Glycopyrronium with, for example, Clozapine, Abobotulinumtoxina, Aclidinium. The full list is on the Glycopyrronium page.
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