Drug interactions
Benperidol + Hydroxyzine
Severity: Major
Benperidol and Hydroxyzine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benperidol is a potent butyrophenone antipsychotic, and combined use with hydroxyzine increases sedation. Both drugs can prolong the QT interval, which raises the risk of arrhythmias including torsades de pointes in susceptible patients.
What this interaction means in plain words
Benperidol and Hydroxyzine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS depression and QT prolongation.
What to do
Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor for sedation and QT prolongation, and use an alternative anxiolytic if risk factors are present.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Benperidol with Hydroxyzine?
MediHelp rates the interaction as major. Benperidol and Hydroxyzine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Benperidol is a potent butyrophenone antipsychotic, and combined use with hydroxyzine increases sedation. Both drugs can prolong the QT interval, which raises the risk of arrhythmias including torsades de pointes in susceptible patients.
How serious is the interaction between Benperidol and Hydroxyzine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor for sedation and QT prolongation, and use an alternative anxiolytic if risk factors are present.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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