Drug interactions
Benperidol + Midazolam
Severity: Moderate
Benperidol and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benperidol is a potent butyrophenone antipsychotic, and combined use with midazolam increases sedation and may cause hypotension. Psychomotor impairment is additive.
What this interaction means in plain words
Benperidol and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A potentiation and dopamine/adrenergic blockade.
What to do
Use reduced doses and monitor sedation, respiration and blood pressure. Advise patients to avoid driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Benperidol with Midazolam?
MediHelp rates the interaction as moderate. Benperidol and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benperidol is a potent butyrophenone antipsychotic, and combined use with midazolam increases sedation and may cause hypotension. Psychomotor impairment is additive.
How serious is the interaction between Benperidol and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use reduced doses and monitor sedation, respiration and blood pressure. Advise patients to avoid driving.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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