Drug interactions
Benperidol + Solifenacin
Severity: Moderate
Benperidol and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benperidol is a butyrophenone antipsychotic that can prolong the QT interval and has some anticholinergic effect. Used with solifenacin it may increase anticholinergic adverse effects and arrhythmic risk.
What this interaction means in plain words
Benperidol and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation and anticholinergic effects.
What to do
Obtain an ECG and check electrolytes in patients with risk factors, and monitor for anticholinergic adverse effects and confusion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Benperidol and Solifenacin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Solifenacin
Frequently asked questions
Can I take Benperidol with Solifenacin?
MediHelp rates the interaction as moderate. Benperidol and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benperidol is a butyrophenone antipsychotic that can prolong the QT interval and has some anticholinergic effect. Used with solifenacin it may increase anticholinergic adverse effects and arrhythmic risk.
How serious is the interaction between Benperidol and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG and check electrolytes in patients with risk factors, and monitor for anticholinergic adverse effects and confusion.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
