Drug interactions
Benzhydrocodone / acetaminophen + Bosentan
Severity: Moderate
Benzhydrocodone / acetaminophen and Bosentan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan may lower hydrocodone levels from benzhydrocodone, reducing analgesia. If bosentan is stopped, hydrocodone concentrations may rise and cause respiratory depression.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Bosentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Bosentan induces CYP3A4, increasing hydrocodone metabolism to inactive metabolites.
What to do
Monitor pain control and for withdrawal when starting bosentan, and for sedation and respiratory depression if it is stopped or the opioid dose is increased.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Benzhydrocodone / acetaminophen and Bosentan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Cyclosporine Contraindicated
- Bosentan + Glyburide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Bosentan?
MediHelp rates the interaction as moderate. Benzhydrocodone / acetaminophen and Bosentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan may lower hydrocodone levels from benzhydrocodone, reducing analgesia. If bosentan is stopped, hydrocodone concentrations may rise and cause respiratory depression.
How serious is the interaction between Benzhydrocodone / acetaminophen and Bosentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pain control and for withdrawal when starting bosentan, and for sedation and respiratory depression if it is stopped or the opioid dose is increased.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Cyclosporine, Glyburide. The full list is on the Bosentan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
