Drug interactions
Benzhydrocodone / acetaminophen + Bupropion-naltrexone
Severity: Major
Benzhydrocodone / acetaminophen and Bupropion-naltrexone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naltrexone is an opioid antagonist and will block or reduce the analgesic effect of benzhydrocodone (hydrocodone). Bupropion's CYP2D6 inhibition may also alter hydrocodone metabolism, and both drugs carry seizure and serotonergic risk. In patients physically dependent on opioids, naltrexone may precipitate withdrawal.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Bupropion-naltrexone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Competitive opioid receptor antagonism by naltrexone, plus CYP2D6 inhibition by bupropion and additive seizure-threshold effects.
What to do
Avoid concurrent use; the opioid should be stopped for at least 7 to 10 days before starting naltrexone-containing therapy. Use non-opioid analgesia if pain control is needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Bupropion-naltrexone?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Bupropion-naltrexone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Naltrexone is an opioid antagonist and will block or reduce the analgesic effect of benzhydrocodone (hydrocodone). Bupropion's CYP2D6 inhibition may also alter hydrocodone metabolism, and both drugs carry seizure and serotonergic risk. In patients physically dependent on opioids, naltrexone may precipitate withdrawal.
How serious is the interaction between Benzhydrocodone / acetaminophen and Bupropion-naltrexone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; the opioid should be stopped for at least 7 to 10 days before starting naltrexone-containing therapy. Use non-opioid analgesia if pain control is needed.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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