Drug interactions
Benzhydrocodone / acetaminophen + Bupropion
Severity: Moderate
Benzhydrocodone / acetaminophen and Bupropion: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion inhibits CYP2D6, which may reduce conversion of hydrocodone to hydromorphone and alter analgesia. Both drugs may also lower seizure threshold, and opioids with serotonergic activity carry a small risk of serotonin toxicity.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Bupropion can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP2D6 inhibition by bupropion alters hydrocodone metabolism, with additive seizure and possible serotonergic effects.
What to do
Monitor analgesic response and for seizures, sedation and serotonin toxicity signs. Adjust opioid dosing based on response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Bupropion?
MediHelp rates the interaction as moderate. Benzhydrocodone / acetaminophen and Bupropion can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bupropion inhibits CYP2D6, which may reduce conversion of hydrocodone to hydromorphone and alter analgesia. Both drugs may also lower seizure threshold, and opioids with serotonergic activity carry a small risk of serotonin toxicity.
How serious is the interaction between Benzhydrocodone / acetaminophen and Bupropion?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesic response and for seizures, sedation and serotonin toxicity signs. Adjust opioid dosing based on response.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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