Drug interactions
Benzhydrocodone / acetaminophen + Clomipramine
Severity: Major
Benzhydrocodone / acetaminophen and Clomipramine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids combined with sedating antidepressants increase the risk of profound sedation and respiratory depression. Clomipramine also inhibits CYP2D6 and may alter opioid activation, and serotonergic effects are possible.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Clomipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression, with possible serotonergic effects and CYP2D6 inhibition by clomipramine.
What to do
Reserve combined use for patients without adequate alternatives and use the lowest effective doses. Monitor for sedation, respiratory depression and serotonin toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Clomipramine?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Clomipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids combined with sedating antidepressants increase the risk of profound sedation and respiratory depression. Clomipramine also inhibits CYP2D6 and may alter opioid activation, and serotonergic effects are possible.
How serious is the interaction between Benzhydrocodone / acetaminophen and Clomipramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve combined use for patients without adequate alternatives and use the lowest effective doses. Monitor for sedation, respiratory depression and serotonin toxicity.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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