Drug interactions
Benzhydrocodone / acetaminophen + Dantrolene
Severity: Major
Benzhydrocodone / acetaminophen and Dantrolene: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dantrolene can cause drowsiness and muscle weakness, and benzhydrocodone is an opioid that causes sedation and respiratory depression. Together they may produce profound sedation, respiratory depression, coma or death, particularly with oral dantrolene.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Dantrolene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive central nervous system and respiratory depression from opioid effects with dantrolene's sedation and muscle weakness.
What to do
Reserve combined use for patients lacking alternatives, using the lowest doses and shortest duration. Monitor for sedation and respiratory depression and counsel patients to avoid driving.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dantrolene
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Dantrolene?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Dantrolene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dantrolene can cause drowsiness and muscle weakness, and benzhydrocodone is an opioid that causes sedation and respiratory depression. Together they may produce profound sedation, respiratory depression, coma or death, particularly with oral dantrolene.
How serious is the interaction between Benzhydrocodone / acetaminophen and Dantrolene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve combined use for patients lacking alternatives, using the lowest doses and shortest duration. Monitor for sedation and respiratory depression and counsel patients to avoid driving.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Buprenorphine long-acting, Buprenorphine subdermal implant, Buprenorphine transdermal. The full list is on the Dantrolene page.
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