Drug reference
dantrolene
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Musculoskeletal (Muscle Relaxants)
Mechanism of action
Interferes with calcium release within skeletal muscle cells (from sarcoplasmic reticulum)
Common side effects
- Increased serum AST (SGOT), ALT (SGPT)
- Anorexia
- Fatal/nonfatal hepatitis
- Gastric irritation
- Diarrhea
Contraindications
- NO CONTRAINDICATIONS for IV use in MH management/prophylaxis Hypersensitivity Impaired hepatic, cardiac or pulmonary function Upper motor neuron disorder Patients in whom spasticity is utilized to maintain upright posture & balance
Known interactions (14)
- dantrolene + diltiazem Major
- dantrolene + felodipine Major
- dantrolene + nicardipine Major
- dantrolene + verapamil Major
- amlodipine + dantrolene Moderate
- amlodipine-atorvastatin + dantrolene Moderate
- amlodipine-benazepril + dantrolene Moderate
- amlodipine-hydrochlorothiazide-valsartan + dantrolene Moderate
- amlodipine-olmesartan + dantrolene Moderate
- amlodipine-olmesartan-hydrochlorothiazide + dantrolene Moderate
- amlodipine-perindopril + dantrolene Moderate
- amlodipine-valsartan + dantrolene Moderate
- dantrolene + gabapentin Moderate
- dantrolene + vecuronium Moderate
Related conditions
Frequently asked questions
What drug class is dantrolene?
dantrolene belongs to: Musculoskeletal.
How does dantrolene work?
Interferes with calcium release within skeletal muscle cells (from sarcoplasmic reticulum)
What are the common side effects of dantrolene?
Increased serum AST (SGOT), ALT (SGPT), Anorexia, Fatal/nonfatal hepatitis, Gastric irritation, Diarrhea
Which drugs interact with dantrolene?
diltiazem, felodipine, nicardipine, verapamil, amlodipine, amlodipine-atorvastatin, amlodipine-benazepril, amlodipine-hydrochlorothiazide-valsartan, amlodipine-olmesartan, amlodipine-olmesartan-hydrochlorothiazide, amlodipine-perindopril, amlodipine-valsartan, gabapentin, vecuronium
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