Drug interactions
Benzhydrocodone / acetaminophen + Dronedarone
Severity: Moderate
Benzhydrocodone / acetaminophen and Dronedarone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone inhibits CYP2D6, which converts hydrocodone to the minor metabolite hydromorphone. The effect on analgesia is likely small, and CYP3A4 inhibition could modestly raise hydrocodone levels and sedation.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP2D6 and CYP3A4 by dronedarone alters hydrocodone metabolism.
What to do
Monitor for sedation, respiratory depression and changes in analgesic response. Adjust the opioid dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Dronedarone?
MediHelp rates the interaction as moderate. Benzhydrocodone / acetaminophen and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone inhibits CYP2D6, which converts hydrocodone to the minor metabolite hydromorphone. The effect on analgesia is likely small, and CYP3A4 inhibition could modestly raise hydrocodone levels and sedation.
How serious is the interaction between Benzhydrocodone / acetaminophen and Dronedarone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, respiratory depression and changes in analgesic response. Adjust the opioid dose as needed.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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