Drug interactions
Benzhydrocodone / acetaminophen + Flibanserin
Severity: Major
Benzhydrocodone / acetaminophen and Flibanserin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids combined with flibanserin raise the risk of profound sedation, respiratory depression, hypotension and syncope. Serotonergic effects are also theoretically possible.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Flibanserin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression, with possible minor serotonergic contribution.
What to do
Avoid combining where possible; if necessary use the lowest opioid dose, and monitor sedation, respiration and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Flibanserin?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Flibanserin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids combined with flibanserin raise the risk of profound sedation, respiratory depression, hypotension and syncope. Serotonergic effects are also theoretically possible.
How serious is the interaction between Benzhydrocodone / acetaminophen and Flibanserin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; if necessary use the lowest opioid dose, and monitor sedation, respiration and blood pressure.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
Full monographs, dosing and an interaction checker in the MediHelp app
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