Drug interactions
Benzhydrocodone / acetaminophen + Haloperidol
Severity: Major
Benzhydrocodone / acetaminophen and Haloperidol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids combined with sedating antipsychotics can cause profound sedation, respiratory depression, hypotension, coma and death. The risk is highest at higher doses and in vulnerable patients.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Haloperidol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression.
What to do
Reserve the combination for patients without alternatives, and use the lowest doses for the shortest duration. Monitor for sedation and respiratory depression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Haloperidol?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Haloperidol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids combined with sedating antipsychotics can cause profound sedation, respiratory depression, hypotension, coma and death. The risk is highest at higher doses and in vulnerable patients.
How serious is the interaction between Benzhydrocodone / acetaminophen and Haloperidol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve the combination for patients without alternatives, and use the lowest doses for the shortest duration. Monitor for sedation and respiratory depression.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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