Drug interactions
Benzhydrocodone / acetaminophen + Paliperidone
Severity: Major
Benzhydrocodone / acetaminophen and Paliperidone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids combined with other CNS depressants such as paliperidone can cause additive sedation, respiratory depression, hypotension and rarely coma or death. Paliperidone is a less potent sedative than many antipsychotics, but the risk remains.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Paliperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression through opioid receptor agonism and antipsychotic sedative and hypotensive effects.
What to do
Use the lowest effective doses for the shortest time and only when alternatives are inadequate. Monitor for sedation and respiratory depression, especially at initiation and dose changes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Paliperidone?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Paliperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids combined with other CNS depressants such as paliperidone can cause additive sedation, respiratory depression, hypotension and rarely coma or death. Paliperidone is a less potent sedative than many antipsychotics, but the risk remains.
How serious is the interaction between Benzhydrocodone / acetaminophen and Paliperidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest time and only when alternatives are inadequate. Monitor for sedation and respiratory depression, especially at initiation and dose changes.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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