Drug interactions
Benzhydrocodone / acetaminophen + Perphenazine
Severity: Major
Benzhydrocodone / acetaminophen and Perphenazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids combined with phenothiazines can cause profound sedation, respiratory depression, hypotension, coma and death. The risk is greater at higher doses and in patients with reduced blood volume.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Perphenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression and additive hypotensive effects.
What to do
Reserve the combination for patients with no alternatives, using the lowest effective doses and shortest duration. Monitor for sedation, respiratory depression and hypotension.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Perphenazine?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Perphenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids combined with phenothiazines can cause profound sedation, respiratory depression, hypotension, coma and death. The risk is greater at higher doses and in patients with reduced blood volume.
How serious is the interaction between Benzhydrocodone / acetaminophen and Perphenazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve the combination for patients with no alternatives, using the lowest effective doses and shortest duration. Monitor for sedation, respiratory depression and hypotension.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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