Drug interactions
Benzhydrocodone / acetaminophen + Promethazine
Severity: Major
Benzhydrocodone / acetaminophen and Promethazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination of promethazine and benzhydrocodone/acetaminophen can lead to enhanced sedation and respiratory depression. This increased sedative effect may pose significant risks, particularly in vulnerable populations or when higher doses are used.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Promethazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Both drugs have central nervous system depressant properties, which can lead to additive effects when administered together.
What to do
Close monitoring for signs of excessive sedation and respiratory depression is recommended if these medications must be used concurrently. Consider alternative therapies when possible to mitigate risks.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Promethazine
- Cabergoline + Promethazine Contraindicated
- Dopamine + Promethazine Contraindicated
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Promethazine?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Promethazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The combination of promethazine and benzhydrocodone/acetaminophen can lead to enhanced sedation and respiratory depression. This increased sedative effect may pose significant risks, particularly in vulnerable populations or when higher doses are used.
How serious is the interaction between Benzhydrocodone / acetaminophen and Promethazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Close monitoring for signs of excessive sedation and respiratory depression is recommended if these medications must be used concurrently. Consider alternative therapies when possible to mitigate risks.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Cabergoline, Dopamine, Ibutilide. The full list is on the Promethazine page.
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