Drug interactions
Benzhydrocodone / acetaminophen + Sevoflurane
Severity: Major
Benzhydrocodone / acetaminophen and Sevoflurane: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids combined with a volatile anesthetic cause additive CNS and respiratory depression and hypotension. Profound sedation, respiratory failure and death are possible.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Sevoflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic CNS and respiratory depression and vasodilation.
What to do
Titrate sevoflurane to effect with reduced requirements expected, and monitor ventilation, oxygenation and blood pressure continuously. Keep opioid doses and durations to the minimum needed and support hypovolemic patients.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sevoflurane
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Sevoflurane?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Sevoflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids combined with a volatile anesthetic cause additive CNS and respiratory depression and hypotension. Profound sedation, respiratory failure and death are possible.
How serious is the interaction between Benzhydrocodone / acetaminophen and Sevoflurane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate sevoflurane to effect with reduced requirements expected, and monitor ventilation, oxygenation and blood pressure continuously. Keep opioid doses and durations to the minimum needed and support hypovolemic patients.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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