Drug interactions
Amisulpride + Sevoflurane
Severity: Major
Amisulpride and Sevoflurane: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amisulpride causes dose-related QT prolongation and sevoflurane is known to lengthen the QT interval. Together they raise the risk of torsades de pointes, particularly at higher amisulpride doses and with electrolyte disturbances.
What this interaction means in plain words
Amisulpride and Sevoflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amisulpride belongs to Central Nervous System; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Check the baseline QTc and correct hypokalemia and hypomagnesemia. Monitor the ECG during anesthesia and recovery, and avoid other QT-prolonging drugs such as ondansetron.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sevoflurane
Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Frequently asked questions
Can I take Amisulpride with Sevoflurane?
MediHelp rates the interaction as major. Amisulpride and Sevoflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amisulpride causes dose-related QT prolongation and sevoflurane is known to lengthen the QT interval. Together they raise the risk of torsades de pointes, particularly at higher amisulpride doses and with electrolyte disturbances.
How serious is the interaction between Amisulpride and Sevoflurane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check the baseline QTc and correct hypokalemia and hypomagnesemia. Monitor the ECG during anesthesia and recovery, and avoid other QT-prolonging drugs such as ondansetron.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Arsenic trioxide, Bedaquiline. The full list is on the Sevoflurane page.
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