Drug interactions
Amiodarone + Sevoflurane
Severity: Major
Amiodarone and Sevoflurane: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sevoflurane prolongs the QT interval and amiodarone does as well, so during anesthesia the risk of torsades de pointes and bradyarrhythmia is increased. Amiodarone may also add to hypotension and bradycardia under anesthesia.
What this interaction means in plain words
Amiodarone and Sevoflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive QTc prolongation and additive negative chronotropic and hypotensive effects.
What to do
Review the preoperative ECG and correct electrolytes before surgery. Monitor ECG continuously during anesthesia and have pacing and antiarrhythmic rescue ready.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Sevoflurane
Frequently asked questions
Can I take Amiodarone with Sevoflurane?
MediHelp rates the interaction as major. Amiodarone and Sevoflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sevoflurane prolongs the QT interval and amiodarone does as well, so during anesthesia the risk of torsades de pointes and bradyarrhythmia is increased. Amiodarone may also add to hypotension and bradycardia under anesthesia.
How serious is the interaction between Amiodarone and Sevoflurane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review the preoperative ECG and correct electrolytes before surgery. Monitor ECG continuously during anesthesia and have pacing and antiarrhythmic rescue ready.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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