Drug interactions
Bedaquiline + Sevoflurane
Severity: Major
Bedaquiline and Sevoflurane: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bedaquiline prolongs the QT interval and its long terminal half-life keeps this effect present for months. Sevoflurane adds further repolarization delay and may increase the risk of torsades de pointes.
What this interaction means in plain words
Bedaquiline and Sevoflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bedaquiline belongs to Anti Bacterial; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive QTc prolongation.
What to do
Review a recent ECG and correct hypokalemia, hypomagnesemia and hypocalcemia before anesthesia. Monitor the ECG continuously and avoid other QT-prolonging drugs, considering alternatives if the QTc is markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sevoflurane
Other interactions of Bedaquiline
- Bedaquiline + Ziprasidone Contraindicated
- Alfuzosin + Bedaquiline Major
- Amiodarone + Bedaquiline Major
- Amisulpride + Bedaquiline Major
- Amitriptyline + Bedaquiline Major
- Amobarbital + Bedaquiline Major
Frequently asked questions
Can I take Bedaquiline with Sevoflurane?
MediHelp rates the interaction as major. Bedaquiline and Sevoflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bedaquiline prolongs the QT interval and its long terminal half-life keeps this effect present for months. Sevoflurane adds further repolarization delay and may increase the risk of torsades de pointes.
How serious is the interaction between Bedaquiline and Sevoflurane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review a recent ECG and correct hypokalemia, hypomagnesemia and hypocalcemia before anesthesia. Monitor the ECG continuously and avoid other QT-prolonging drugs, considering alternatives if the QTc is markedly prolonged.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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