Drug interactions
Benzhydrocodone / acetaminophen + Succinylcholine
Severity: Moderate
Benzhydrocodone / acetaminophen and Succinylcholine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids depress respiration and succinylcholine paralyzes respiratory muscles, so both together increase the risk of hypoventilation if ventilation is not controlled. Succinylcholine is normally used with airway management, which limits this risk.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Central opioid respiratory depression adds to neuromuscular blockade of respiratory muscles.
What to do
Use only with airway control and ventilatory support. Monitor respiration through recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Succinylcholine
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Succinylcholine?
MediHelp rates the interaction as moderate. Benzhydrocodone / acetaminophen and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids depress respiration and succinylcholine paralyzes respiratory muscles, so both together increase the risk of hypoventilation if ventilation is not controlled. Succinylcholine is normally used with airway management, which limits this risk.
How serious is the interaction between Benzhydrocodone / acetaminophen and Succinylcholine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only with airway control and ventilatory support. Monitor respiration through recovery.
What other medicines interact with Succinylcholine?
MediHelp also lists interactions of Succinylcholine with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Succinylcholine page.
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