Drug interactions
Benzhydrocodone / acetaminophen + Zolmitriptan
Severity: Moderate
Benzhydrocodone / acetaminophen and Zolmitriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzhydrocodone is an opioid prodrug of hydrocodone, and serotonin syndrome with opioids and triptans has been reported rarely. The risk is low but potentially serious.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Zolmitriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive serotonergic effects; hydrocodone has weak serotonergic activity.
What to do
Monitor for clonus, agitation, hyperthermia and autonomic instability, especially at initiation and dose increases. Discontinue if serotonin syndrome develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zolmitriptan
- Almotriptan + Zolmitriptan Contraindicated
- Dihydroergotamine intranasal + Zolmitriptan Contraindicated
- Dihydroergotamine + Zolmitriptan Contraindicated
- Eletriptan + Zolmitriptan Contraindicated
- Ergoloid mesylates + Zolmitriptan Contraindicated
- Ergotamine + Zolmitriptan Contraindicated
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Zolmitriptan?
MediHelp rates the interaction as moderate. Benzhydrocodone / acetaminophen and Zolmitriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benzhydrocodone is an opioid prodrug of hydrocodone, and serotonin syndrome with opioids and triptans has been reported rarely. The risk is low but potentially serious.
How serious is the interaction between Benzhydrocodone / acetaminophen and Zolmitriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for clonus, agitation, hyperthermia and autonomic instability, especially at initiation and dose increases. Discontinue if serotonin syndrome develops.
What other medicines interact with Zolmitriptan?
MediHelp also lists interactions of Zolmitriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Zolmitriptan page.
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