Drug interactions
Benzoyl peroxide + Methoxsalen
Severity: Moderate
Benzoyl peroxide and Methoxsalen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzoyl peroxide can irritate skin and has been linked to photosensitivity in some users, while methoxsalen strongly sensitizes skin to UVA. Together they may increase the risk of phototoxic burns.
What this interaction means in plain words
Benzoyl peroxide and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benzoyl peroxide belongs to Dermatology; Methoxsalen belongs to Anti Fungals.
Why it happens
Additive skin irritation and photosensitizing effects, although the contribution of benzoyl peroxide is modest.
What to do
Avoid applying benzoyl peroxide to skin exposed to PUVA around treatment sessions. Monitor for erythema and adjust UVA exposure if irritation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
Other interactions of Benzoyl peroxide
Frequently asked questions
Can I take Benzoyl peroxide with Methoxsalen?
MediHelp rates the interaction as moderate. Benzoyl peroxide and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benzoyl peroxide can irritate skin and has been linked to photosensitivity in some users, while methoxsalen strongly sensitizes skin to UVA. Together they may increase the risk of phototoxic burns.
How serious is the interaction between Benzoyl peroxide and Methoxsalen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid applying benzoyl peroxide to skin exposed to PUVA around treatment sessions. Monitor for erythema and adjust UVA exposure if irritation develops.
What other medicines interact with Methoxsalen?
MediHelp also lists interactions of Methoxsalen with, for example, Fezolinetant, Demeclocycline, Fedratinib. The full list is on the Methoxsalen page.
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