Drug interactions
Benzphetamine + Clomipramine
Severity: Moderate
Benzphetamine and Clomipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants may alter the pressor response to sympathomimetic amines such as benzphetamine, leading to hypertension, tachycardia or arrhythmia. Effects can be unpredictable, and the stimulant may also reduce the antidepressant effect.
What this interaction means in plain words
Benzphetamine and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Altered neuronal uptake of norepinephrine and indirect sympathomimetics, producing additive or unpredictable adrenergic effects.
What to do
Monitor blood pressure and heart rate and avoid in patients with cardiovascular disease. Stop benzphetamine if hypertension or arrhythmia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Benzphetamine with Clomipramine?
MediHelp rates the interaction as moderate. Benzphetamine and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants may alter the pressor response to sympathomimetic amines such as benzphetamine, leading to hypertension, tachycardia or arrhythmia. Effects can be unpredictable, and the stimulant may also reduce the antidepressant effect.
How serious is the interaction between Benzphetamine and Clomipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and avoid in patients with cardiovascular disease. Stop benzphetamine if hypertension or arrhythmia develops.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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