Drug interactions
Benzphetamine + Clorazepate
Severity: Minor
Benzphetamine and Clorazepate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzphetamine is a stimulant anorectic that may partially counteract benzodiazepine sedation. The clinical effect is unpredictable and usually modest.
What this interaction means in plain words
Benzphetamine and Clorazepate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic opposition between sympathomimetic CNS stimulation and GABAergic sedation; not well characterised.
What to do
No dose adjustment is routinely needed. Monitor for anxiety, insomnia or reduced anxiolytic benefit.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Benzphetamine and Clorazepate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Frequently asked questions
Can I take Benzphetamine with Clorazepate?
MediHelp rates the interaction as minor. Benzphetamine and Clorazepate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Benzphetamine is a stimulant anorectic that may partially counteract benzodiazepine sedation. The clinical effect is unpredictable and usually modest.
How serious is the interaction between Benzphetamine and Clorazepate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is routinely needed. Monitor for anxiety, insomnia or reduced anxiolytic benefit.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
