Drug interactions
Benzphetamine + Hydromorphone
Severity: Minor
Benzphetamine and Hydromorphone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzphetamine is a sympathomimetic anorectic whose stimulant effect may partly offset opioid sedation, but this is unreliable. Opioid-related respiratory depression is not prevented.
What this interaction means in plain words
Benzphetamine and Hydromorphone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic opposition between CNS stimulation and opioid depression; not well characterized.
What to do
Do not use benzphetamine to counter opioid effects; monitor sedation, respiration and blood pressure.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydromorphone
- Alvimopan + Hydromorphone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Hydromorphone + Isocarboxazid Contraindicated
- Hydromorphone + Olanzapine / samidorphan Contraindicated
- Hydromorphone + Phenelzine Contraindicated
- Hydromorphone + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Benzphetamine with Hydromorphone?
MediHelp rates the interaction as minor. Benzphetamine and Hydromorphone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Benzphetamine is a sympathomimetic anorectic whose stimulant effect may partly offset opioid sedation, but this is unreliable. Opioid-related respiratory depression is not prevented.
How serious is the interaction between Benzphetamine and Hydromorphone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use benzphetamine to counter opioid effects; monitor sedation, respiration and blood pressure.
What other medicines interact with Hydromorphone?
MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydromorphone page.
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