Drug interactions
Hydromorphone + Isocarboxazid
Severity: Contraindicated
Hydromorphone and Isocarboxazid: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids combined with nonselective MAOIs have caused serious reactions including hypotension, hyperthermia, agitation, coma and respiratory depression. Hydromorphone labeling advises against use with MAOIs or within 14 days of stopping them.
What this interaction means in plain words
Hydromorphone and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Hydromorphone belongs to Musculoskeletal; Isocarboxazid belongs to Central Nervous System.
Why it happens
Irreversible MAO inhibition may potentiate opioid CNS and respiratory depression and cause serotonergic or autonomic instability; the exact mechanism is not fully defined.
What to do
Do not use together and allow at least 14 days after stopping the MAOI before starting hydromorphone. Use a non-serotonergic alternative analgesic if needed.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydromorphone and Isocarboxazid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Hydromorphone
- Alvimopan + Hydromorphone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Hydromorphone + Olanzapine / samidorphan Contraindicated
- Hydromorphone + Phenelzine Contraindicated
- Hydromorphone + Tranylcypromine Contraindicated
- Alfentanil + Hydromorphone Major
Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Hydromorphone with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Hydromorphone and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Opioids combined with nonselective MAOIs have caused serious reactions including hypotension, hyperthermia, agitation, coma and respiratory depression. Hydromorphone labeling advises against use with MAOIs or within 14 days of stopping them.
How serious is the interaction between Hydromorphone and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together and allow at least 14 days after stopping the MAOI before starting hydromorphone. Use a non-serotonergic alternative analgesic if needed.
What other medicines interact with Hydromorphone?
MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Olanzapine / samidorphan. The full list is on the Hydromorphone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
