Drug interactions
Benzphetamine + Midazolam
Severity: Minor
Benzphetamine and Midazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzphetamine is a stimulant anorectic that could partly offset midazolam sedation. The combined effect is unpredictable and not well documented.
What this interaction means in plain words
Benzphetamine and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing pharmacodynamic effects of sympathomimetic stimulation and GABAergic sedation.
What to do
No routine action is needed. Titrate midazolam to clinical effect and do not treat stimulant effects as a sign of adequate sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Benzphetamine with Midazolam?
MediHelp rates the interaction as minor. Benzphetamine and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Benzphetamine is a stimulant anorectic that could partly offset midazolam sedation. The combined effect is unpredictable and not well documented.
How serious is the interaction between Benzphetamine and Midazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Titrate midazolam to clinical effect and do not treat stimulant effects as a sign of adequate sedation.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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