Drug interactions
Benztropine + Clomipramine
Severity: Moderate
Benztropine and Clomipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have strong antimuscarinic activity, so together they may cause marked dry mouth, constipation, urinary retention, confusion, tachycardia and even paralytic ileus or hyperthermia. Older patients are particularly susceptible.
What this interaction means in plain words
Benztropine and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benztropine belongs to Central Nervous System; Clomipramine belongs to Central Nervous System.
Why it happens
Additive muscarinic receptor blockade.
What to do
Monitor for anticholinergic toxicity, including cognition and bowel and bladder function, and use the lowest effective benztropine dose. Reassess the need for benztropine regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Benztropine
- Benztropine + Memantine-donepezil Major
- Abobotulinumtoxina + Benztropine Moderate
- Amantadine + Benztropine Moderate
- Amitriptyline + Benztropine Moderate
- Amoxapine + Benztropine Moderate
- Atropine iv / + Benztropine Moderate
Frequently asked questions
Can I take Benztropine with Clomipramine?
MediHelp rates the interaction as moderate. Benztropine and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have strong antimuscarinic activity, so together they may cause marked dry mouth, constipation, urinary retention, confusion, tachycardia and even paralytic ileus or hyperthermia. Older patients are particularly susceptible.
How serious is the interaction between Benztropine and Clomipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, including cognition and bowel and bladder function, and use the lowest effective benztropine dose. Reassess the need for benztropine regularly.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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