Drug interactions
Berotralstat + Brentuximab
Severity: Moderate
Berotralstat and Brentuximab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Berotralstat inhibits P-glycoprotein, and MMAE from brentuximab vedotin is a P-gp substrate. Exposure to MMAE may rise modestly, increasing the potential for neutropenia and neuropathy.
What this interaction means in plain words
Berotralstat and Brentuximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Berotralstat belongs to Miscellaneous; Brentuximab belongs to Oncology.
Why it happens
P-gp inhibition reduces efflux of MMAE, increasing its exposure; berotralstat also inhibits CYP3A4.
What to do
Monitor blood counts and neuropathy during co-treatment. Reduce or hold brentuximab doses if hematologic or neurologic toxicity emerges.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brentuximab
- Bleomycin + Brentuximab Contraindicated
- Brentuximab + Dengue vaccine Major
- Brentuximab + Etrasimod Major
- Brentuximab + Idelalisib Major
- Brentuximab + Levoketoconazole Major
- Brentuximab + Nefazodone Major
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Brentuximab?
MediHelp rates the interaction as moderate. Berotralstat and Brentuximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Berotralstat inhibits P-glycoprotein, and MMAE from brentuximab vedotin is a P-gp substrate. Exposure to MMAE may rise modestly, increasing the potential for neutropenia and neuropathy.
How serious is the interaction between Berotralstat and Brentuximab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy during co-treatment. Reduce or hold brentuximab doses if hematologic or neurologic toxicity emerges.
What other medicines interact with Brentuximab?
MediHelp also lists interactions of Brentuximab with, for example, Bleomycin, Dengue vaccine, Etrasimod. The full list is on the Brentuximab page.
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