Drug interactions
Berotralstat + Eltrombopag
Severity: Moderate
Berotralstat and Eltrombopag: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Berotralstat is a BCRP substrate, and eltrombopag inhibits BCRP. Berotralstat exposure may increase, with more gastrointestinal and QT-related adverse effects.
What this interaction means in plain words
Berotralstat and Eltrombopag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Berotralstat belongs to Miscellaneous; Eltrombopag belongs to Miscellaneous.
Why it happens
Eltrombopag inhibits BCRP efflux transport, which may raise berotralstat absorption and exposure.
What to do
Monitor for berotralstat adverse effects such as gastrointestinal upset, and consider an ECG if risk factors for QT prolongation are present. Reduce the berotralstat dose if it is poorly tolerated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Eltrombopag?
MediHelp rates the interaction as moderate. Berotralstat and Eltrombopag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Berotralstat is a BCRP substrate, and eltrombopag inhibits BCRP. Berotralstat exposure may increase, with more gastrointestinal and QT-related adverse effects.
How serious is the interaction between Berotralstat and Eltrombopag?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for berotralstat adverse effects such as gastrointestinal upset, and consider an ECG if risk factors for QT prolongation are present. Reduce the berotralstat dose if it is poorly tolerated.
What other medicines interact with Eltrombopag?
MediHelp also lists interactions of Eltrombopag with, for example, Alpelisib, Aluminum hydroxide, Amobarbital. The full list is on the Eltrombopag page.
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