Drug interactions
Berotralstat + Imatinib
Severity: Moderate
Berotralstat and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Berotralstat is a substrate of P-gp and BCRP, and it inhibits P-gp, BCRP and CYP enzymes. Each drug may raise the other's exposure modestly, with possible increases in gastrointestinal effects or QT effects of berotralstat.
What this interaction means in plain words
Berotralstat and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Berotralstat belongs to Miscellaneous; Imatinib belongs to Oncology.
Why it happens
Imatinib inhibits BCRP and P-gp, raising berotralstat exposure, while berotralstat inhibits P-gp and raises imatinib exposure.
What to do
Monitor for adverse effects of both drugs, including gastrointestinal symptoms and QT prolongation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Berotralstat and Imatinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Imatinib?
MediHelp rates the interaction as moderate. Berotralstat and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Berotralstat is a substrate of P-gp and BCRP, and it inhibits P-gp, BCRP and CYP enzymes. Each drug may raise the other's exposure modestly, with possible increases in gastrointestinal effects or QT effects of berotralstat.
How serious is the interaction between Berotralstat and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects of both drugs, including gastrointestinal symptoms and QT prolongation.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
