Drug interactions
Berotralstat + Lapatinib
Severity: Moderate
Berotralstat and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib inhibits P-gp and BCRP and may raise berotralstat concentrations, while berotralstat, a P-gp inhibitor, may raise lapatinib levels. Increased exposure to either drug may worsen adverse effects, including QT prolongation with berotralstat and gastrointestinal effects or hepatotoxicity with lapatinib.
What this interaction means in plain words
Berotralstat and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Berotralstat belongs to Miscellaneous; Lapatinib belongs to Oncology.
Why it happens
Mutual inhibition of P-glycoprotein and BCRP efflux transport increases absorption and reduces elimination.
What to do
Monitor for gastrointestinal effects, QT prolongation and liver enzyme elevation. Consider an ECG at baseline and after starting the combination.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Berotralstat and Lapatinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Lapatinib?
MediHelp rates the interaction as moderate. Berotralstat and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib inhibits P-gp and BCRP and may raise berotralstat concentrations, while berotralstat, a P-gp inhibitor, may raise lapatinib levels. Increased exposure to either drug may worsen adverse effects, including QT prolongation with berotralstat and gastrointestinal effects or hepatotoxicity with lapatinib.
How serious is the interaction between Berotralstat and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for gastrointestinal effects, QT prolongation and liver enzyme elevation. Consider an ECG at baseline and after starting the combination.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
