Drug interactions
Berotralstat + Linagliptin-metformin
Severity: Minor
Berotralstat and Linagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Berotralstat inhibits P-gp and may raise linagliptin concentrations. Because linagliptin has a wide margin of safety, clinically important effects are unlikely.
What this interaction means in plain words
Berotralstat and Linagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Berotralstat belongs to Miscellaneous; Linagliptin-metformin belongs to Endocrine.
Why it happens
Inhibition of P-glycoprotein reduces linagliptin efflux.
What to do
No dose adjustment is generally needed; monitor glycemic response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linagliptin-metformin
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Linagliptin-metformin?
MediHelp rates the interaction as minor. Berotralstat and Linagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Berotralstat inhibits P-gp and may raise linagliptin concentrations. Because linagliptin has a wide margin of safety, clinically important effects are unlikely.
How serious is the interaction between Berotralstat and Linagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed; monitor glycemic response.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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