Drug interactions
Berotralstat + Nicardipine
Severity: Moderate
Berotralstat and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Berotralstat inhibits P-gp and CYP3A4 and may raise nicardipine exposure, causing hypotension, flushing and oedema. Berotralstat can also prolong the QT interval at higher doses.
What this interaction means in plain words
Berotralstat and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Berotralstat belongs to Miscellaneous; Nicardipine belongs to Cardiovascular.
Why it happens
Inhibition of P-gp and CYP3A4 by berotralstat reduces nicardipine clearance.
What to do
Monitor blood pressure and heart rate after starting berotralstat. Reduce the nicardipine dose if hypotension or related effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Nicardipine?
MediHelp rates the interaction as moderate. Berotralstat and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Berotralstat inhibits P-gp and CYP3A4 and may raise nicardipine exposure, causing hypotension, flushing and oedema. Berotralstat can also prolong the QT interval at higher doses.
How serious is the interaction between Berotralstat and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate after starting berotralstat. Reduce the nicardipine dose if hypotension or related effects occur.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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