Drug interactions
Berotralstat + Paclitaxel
Severity: Moderate
Berotralstat and Paclitaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Berotralstat inhibits P-glycoprotein and may raise paclitaxel concentrations. This could increase neutropenia and neuropathy, though clinical data are limited.
What this interaction means in plain words
Berotralstat and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Berotralstat belongs to Miscellaneous; Paclitaxel belongs to Oncology.
Why it happens
P-glycoprotein inhibition by berotralstat reduces paclitaxel efflux and clearance.
What to do
Monitor blood counts and neuropathy symptoms. Reduce the paclitaxel dose if toxicity increases.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paclitaxel
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Paclitaxel?
MediHelp rates the interaction as moderate. Berotralstat and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Berotralstat inhibits P-glycoprotein and may raise paclitaxel concentrations. This could increase neutropenia and neuropathy, though clinical data are limited.
How serious is the interaction between Berotralstat and Paclitaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy symptoms. Reduce the paclitaxel dose if toxicity increases.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporin. The full list is on the Paclitaxel page.
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