Drug interactions
Berotralstat + Propafenone
Severity: Moderate
Berotralstat and Propafenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propafenone is a P-glycoprotein inhibitor and berotralstat is a P-gp substrate, so berotralstat exposure may increase. Higher levels raise the risk of gastrointestinal effects and QT prolongation, which berotralstat can cause at higher doses.
What this interaction means in plain words
Berotralstat and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Berotralstat belongs to Miscellaneous; Propafenone belongs to Cardiovascular.
Why it happens
Propafenone inhibits P-glycoprotein efflux, increasing berotralstat absorption and exposure.
What to do
Monitor for adverse effects and ECG changes, particularly QTc. Consider reducing berotralstat dose if tolerability is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Propafenone?
MediHelp rates the interaction as moderate. Berotralstat and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propafenone is a P-glycoprotein inhibitor and berotralstat is a P-gp substrate, so berotralstat exposure may increase. Higher levels raise the risk of gastrointestinal effects and QT prolongation, which berotralstat can cause at higher doses.
How serious is the interaction between Berotralstat and Propafenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects and ECG changes, particularly QTc. Consider reducing berotralstat dose if tolerability is poor.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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