Drug interactions
Berotralstat + Regorafenib
Severity: Moderate
Berotralstat and Regorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regorafenib inhibits BCRP and may increase systemic exposure to berotralstat, a BCRP substrate. This may increase berotralstat adverse effects such as gastrointestinal upset and QT prolongation at higher exposures.
What this interaction means in plain words
Berotralstat and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Berotralstat belongs to Miscellaneous; Regorafenib belongs to Oncology.
Why it happens
Inhibition of intestinal and hepatic BCRP efflux transport by regorafenib reduces berotralstat efflux and clearance.
What to do
Monitor for berotralstat adverse effects, especially gastrointestinal symptoms and QT prolongation. Consider ECG monitoring if other QT-prolonging drugs are used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Regorafenib
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Regorafenib?
MediHelp rates the interaction as moderate. Berotralstat and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Regorafenib inhibits BCRP and may increase systemic exposure to berotralstat, a BCRP substrate. This may increase berotralstat adverse effects such as gastrointestinal upset and QT prolongation at higher exposures.
How serious is the interaction between Berotralstat and Regorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for berotralstat adverse effects, especially gastrointestinal symptoms and QT prolongation. Consider ECG monitoring if other QT-prolonging drugs are used.
What other medicines interact with Regorafenib?
MediHelp also lists interactions of Regorafenib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Regorafenib page.
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