Drug interactions
Berotralstat + Sitagliptin
Severity: Minor
Berotralstat and Sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Berotralstat inhibits P-glycoprotein, and sitagliptin is partly eliminated as an unchanged P-gp substrate. Sitagliptin exposure may therefore rise modestly. Sitagliptin has a wide safety margin, so clinically meaningful toxicity is unlikely.
What this interaction means in plain words
Berotralstat and Sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Berotralstat belongs to Miscellaneous; Sitagliptin belongs to Endocrine.
Why it happens
Inhibition of P-glycoprotein efflux by berotralstat, reducing sitagliptin clearance.
What to do
No dose change is usually needed. Monitor glucose and watch for sitagliptin adverse effects such as pancreatitis symptoms or hypoglycemia with co-therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sitagliptin
- Albiglutide + Sitagliptin Moderate
- Amlodipine-benazepril + Sitagliptin Moderate
- Aripiprazole + Sitagliptin Moderate
- Asenapine + Sitagliptin Moderate
- Benazepril + Sitagliptin Moderate
- Captopril-hydrochlorothiazide + Sitagliptin Moderate
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Sitagliptin?
MediHelp rates the interaction as minor. Berotralstat and Sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Berotralstat inhibits P-glycoprotein, and sitagliptin is partly eliminated as an unchanged P-gp substrate. Sitagliptin exposure may therefore rise modestly. Sitagliptin has a wide safety margin, so clinically meaningful toxicity is unlikely.
How serious is the interaction between Berotralstat and Sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Monitor glucose and watch for sitagliptin adverse effects such as pancreatitis symptoms or hypoglycemia with co-therapy.
What other medicines interact with Sitagliptin?
MediHelp also lists interactions of Sitagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Sitagliptin page.
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