Drug interactions
Berotralstat + Verapamil
Severity: Moderate
Berotralstat and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil is a P-gp substrate and inhibitor, and berotralstat is a P-gp inhibitor and substrate, so each may increase the other's concentrations. Berotralstat also prolongs QT at higher doses, so increased exposure may matter.
What this interaction means in plain words
Berotralstat and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Berotralstat belongs to Miscellaneous; Verapamil belongs to Cardiovascular.
Why it happens
Bidirectional P-glycoprotein inhibition (and berotralstat CYP3A4 inhibition) raises exposure of both drugs.
What to do
Monitor heart rate, blood pressure and ECG; consider reducing doses of either drug if bradycardia, hypotension or QT prolongation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Berotralstat and Verapamil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Verapamil?
MediHelp rates the interaction as moderate. Berotralstat and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil is a P-gp substrate and inhibitor, and berotralstat is a P-gp inhibitor and substrate, so each may increase the other's concentrations. Berotralstat also prolongs QT at higher doses, so increased exposure may matter.
How serious is the interaction between Berotralstat and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG; consider reducing doses of either drug if bradycardia, hypotension or QT prolongation develops.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
