Drug interactions
Berotralstat + Vinblastine
Severity: Moderate
Berotralstat and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Berotralstat inhibits P-glycoprotein and may raise exposure to vinblastine, a P-gp substrate with a narrow therapeutic index. This could increase vinblastine toxicities such as myelosuppression, neurotoxicity and constipation or ileus.
What this interaction means in plain words
Berotralstat and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Berotralstat belongs to Miscellaneous; Vinblastine belongs to Oncology.
Why it happens
Berotralstat inhibits P-gp efflux of vinblastine, increasing its systemic exposure.
What to do
Monitor blood counts and for neurotoxicity and gastrointestinal effects during coadministration. Consider reducing the vinblastine dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinblastine
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Vinblastine?
MediHelp rates the interaction as moderate. Berotralstat and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Berotralstat inhibits P-glycoprotein and may raise exposure to vinblastine, a P-gp substrate with a narrow therapeutic index. This could increase vinblastine toxicities such as myelosuppression, neurotoxicity and constipation or ileus.
How serious is the interaction between Berotralstat and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for neurotoxicity and gastrointestinal effects during coadministration. Consider reducing the vinblastine dose if toxicity appears.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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