Drug interactions
Betaxolol + Bupropion
Severity: Moderate
Betaxolol and Bupropion: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion may increase betaxolol exposure through CYP2D6 inhibition, which can enhance beta-blockade with bradycardia or hypotension.
What this interaction means in plain words
Betaxolol and Bupropion can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Betaxolol belongs to Cardiovascular; Bupropion belongs to Central Nervous System.
Why it happens
Inhibition of CYP2D6-mediated betaxolol metabolism by bupropion.
What to do
Monitor heart rate and blood pressure after starting or stopping bupropion. Reduce the betaxolol dose if bradycardia or hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Other interactions of Betaxolol
- Acebutolol + Betaxolol Major
- Aldesleukin + Betaxolol Major
- Amifostine + Betaxolol Major
- Amiodarone + Betaxolol Major
- Atenolol-chlorthalidone + Betaxolol Major
- Atenolol + Betaxolol Major
Frequently asked questions
Can I take Betaxolol with Bupropion?
MediHelp rates the interaction as moderate. Betaxolol and Bupropion can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bupropion may increase betaxolol exposure through CYP2D6 inhibition, which can enhance beta-blockade with bradycardia or hypotension.
How serious is the interaction between Betaxolol and Bupropion?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure after starting or stopping bupropion. Reduce the betaxolol dose if bradycardia or hypotension develops.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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