Drug interactions
Betaxolol + Eliglustat
Severity: Moderate
Betaxolol and Eliglustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat inhibits CYP2D6, which contributes to betaxolol metabolism. Exposure to betaxolol may rise, increasing bradycardia and hypotension.
What this interaction means in plain words
Betaxolol and Eliglustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Betaxolol belongs to Cardiovascular; Eliglustat belongs to Miscellaneous.
Why it happens
Inhibition of CYP2D6-mediated betaxolol metabolism.
What to do
Monitor heart rate and blood pressure, and consider reducing the betaxolol dose if bradycardia or hypotension appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Betaxolol
- Acebutolol + Betaxolol Major
- Aldesleukin + Betaxolol Major
- Amifostine + Betaxolol Major
- Amiodarone + Betaxolol Major
- Atenolol-chlorthalidone + Betaxolol Major
- Atenolol + Betaxolol Major
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Betaxolol with Eliglustat?
MediHelp rates the interaction as moderate. Betaxolol and Eliglustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eliglustat inhibits CYP2D6, which contributes to betaxolol metabolism. Exposure to betaxolol may rise, increasing bradycardia and hypotension.
How serious is the interaction between Betaxolol and Eliglustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure, and consider reducing the betaxolol dose if bradycardia or hypotension appears.
What other medicines interact with Betaxolol?
MediHelp also lists interactions of Betaxolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Betaxolol page.
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