Drug interactions
Betaxolol + Esmolol
Severity: Moderate
Betaxolol and Esmolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are beta-1 selective blockers, so combining them duplicates therapy. Because esmolol is given intravenously, the additive effect can quickly cause bradycardia, hypotension or AV block.
What this interaction means in plain words
Betaxolol and Esmolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Betaxolol belongs to Cardiovascular; Esmolol belongs to Cardiovascular.
Why it happens
Additive beta-1 adrenergic blockade.
What to do
Monitor heart rate, blood pressure and ECG continuously during esmolol infusion in patients on oral betaxolol and titrate esmolol conservatively. Reduce or stop the infusion for significant bradycardia or hypotension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Other interactions of Betaxolol
- Acebutolol + Betaxolol Major
- Aldesleukin + Betaxolol Major
- Amifostine + Betaxolol Major
- Amiodarone + Betaxolol Major
- Atenolol-chlorthalidone + Betaxolol Major
- Atenolol + Betaxolol Major
Frequently asked questions
Can I take Betaxolol with Esmolol?
MediHelp rates the interaction as moderate. Betaxolol and Esmolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are beta-1 selective blockers, so combining them duplicates therapy. Because esmolol is given intravenously, the additive effect can quickly cause bradycardia, hypotension or AV block.
How serious is the interaction between Betaxolol and Esmolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG continuously during esmolol infusion in patients on oral betaxolol and titrate esmolol conservatively. Reduce or stop the infusion for significant bradycardia or hypotension.
What other medicines interact with Esmolol?
MediHelp also lists interactions of Esmolol with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Esmolol page.
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