Drug interactions
Betaxolol + Ivabradine
Severity: Moderate
Betaxolol and Ivabradine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivabradine lowers heart rate by inhibiting the sinus node, and betaxolol slows heart rate through beta-1 blockade. Together they can cause excessive bradycardia or conduction problems.
What this interaction means in plain words
Betaxolol and Ivabradine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Betaxolol belongs to Cardiovascular; Ivabradine belongs to Cardiovascular.
Why it happens
Additive negative chronotropic effects through different mechanisms (If channel inhibition and beta-adrenergic blockade).
What to do
Monitor heart rate and ECG during initiation and dose changes. Reduce or stop ivabradine if resting heart rate falls below about 50 bpm or symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Betaxolol
- Acebutolol + Betaxolol Major
- Aldesleukin + Betaxolol Major
- Amifostine + Betaxolol Major
- Amiodarone + Betaxolol Major
- Atenolol-chlorthalidone + Betaxolol Major
- Atenolol + Betaxolol Major
Other interactions of Ivabradine
- Atazanavir + Ivabradine Contraindicated
- Clarithromycin + Ivabradine Contraindicated
- Cobicistat + Ivabradine Contraindicated
- Conivaptan + Ivabradine Contraindicated
- Darunavir + Ivabradine Contraindicated
- Diltiazem + Ivabradine Contraindicated
Frequently asked questions
Can I take Betaxolol with Ivabradine?
MediHelp rates the interaction as moderate. Betaxolol and Ivabradine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivabradine lowers heart rate by inhibiting the sinus node, and betaxolol slows heart rate through beta-1 blockade. Together they can cause excessive bradycardia or conduction problems.
How serious is the interaction between Betaxolol and Ivabradine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG during initiation and dose changes. Reduce or stop ivabradine if resting heart rate falls below about 50 bpm or symptoms occur.
What other medicines interact with Betaxolol?
MediHelp also lists interactions of Betaxolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Betaxolol page.
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