Drug interactions
Betaxolol + Losartan
Severity: Moderate
Betaxolol and Losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Betaxolol and losartan are commonly combined and both lower blood pressure, so additive hypotension can occur, especially at initiation or with volume depletion. Beta-blockers can modestly raise potassium, adding to the hyperkalemic tendency of losartan.
What this interaction means in plain words
Betaxolol and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Betaxolol belongs to Cardiovascular; Losartan belongs to Cardiovascular.
Why it happens
Additive antihypertensive pharmacodynamic effects, with angiotensin receptor blockade reducing aldosterone and beta-blockade impairing cellular potassium uptake.
What to do
Monitor blood pressure and serum potassium, particularly after starting or adjusting doses and in patients with renal impairment. Losartan must be avoided in pregnancy regardless of this combination.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Betaxolol
- Acebutolol + Betaxolol Major
- Aldesleukin + Betaxolol Major
- Amifostine + Betaxolol Major
- Amiodarone + Betaxolol Major
- Atenolol-chlorthalidone + Betaxolol Major
- Atenolol + Betaxolol Major
Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Betaxolol with Losartan?
MediHelp rates the interaction as moderate. Betaxolol and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Betaxolol and losartan are commonly combined and both lower blood pressure, so additive hypotension can occur, especially at initiation or with volume depletion. Beta-blockers can modestly raise potassium, adding to the hyperkalemic tendency of losartan.
How serious is the interaction between Betaxolol and Losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum potassium, particularly after starting or adjusting doses and in patients with renal impairment. Losartan must be avoided in pregnancy regardless of this combination.
What other medicines interact with Betaxolol?
MediHelp also lists interactions of Betaxolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Betaxolol page.
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