Drug interactions
Betaxolol + Nisoldipine
Severity: Moderate
Betaxolol and Nisoldipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination of a beta-blocker with a dihydropyridine calcium channel blocker has additive blood pressure lowering. This can be beneficial but may cause excessive hypotension, particularly in the early phase of therapy.
What this interaction means in plain words
Betaxolol and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Betaxolol belongs to Cardiovascular; Nisoldipine belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effect of beta-blockade and arterial vasodilation.
What to do
Monitor blood pressure and heart rate when starting or changing doses. Titrate each agent gradually.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Betaxolol
- Acebutolol + Betaxolol Major
- Aldesleukin + Betaxolol Major
- Amifostine + Betaxolol Major
- Amiodarone + Betaxolol Major
- Atenolol-chlorthalidone + Betaxolol Major
- Atenolol + Betaxolol Major
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
Frequently asked questions
Can I take Betaxolol with Nisoldipine?
MediHelp rates the interaction as moderate. Betaxolol and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The combination of a beta-blocker with a dihydropyridine calcium channel blocker has additive blood pressure lowering. This can be beneficial but may cause excessive hypotension, particularly in the early phase of therapy.
How serious is the interaction between Betaxolol and Nisoldipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or changing doses. Titrate each agent gradually.
What other medicines interact with Betaxolol?
MediHelp also lists interactions of Betaxolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Betaxolol page.
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