Drug interactions
Carbamazepine + Nisoldipine
Severity: Major
Carbamazepine and Nisoldipine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine greatly reduces nisoldipine bioavailability, which can cause loss of antihypertensive effect.
What this interaction means in plain words
Carbamazepine and Nisoldipine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carbamazepine belongs to Central Nervous System; Nisoldipine belongs to Cardiovascular.
Why it happens
Carbamazepine induces intestinal and hepatic CYP3A4, increasing first-pass metabolism of nisoldipine.
What to do
Avoid the combination per labeling and use an alternative antihypertensive such as one from a different class. Monitor blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
- Cyclosporin + Nisoldipine Major
Frequently asked questions
Can I take Carbamazepine with Nisoldipine?
MediHelp rates the interaction as major. Carbamazepine and Nisoldipine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbamazepine greatly reduces nisoldipine bioavailability, which can cause loss of antihypertensive effect.
How serious is the interaction between Carbamazepine and Nisoldipine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination per labeling and use an alternative antihypertensive such as one from a different class. Monitor blood pressure.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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